The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. Can diet help improve depression symptoms? This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Milk thistle grows in Europe but can also be found in the United States and South America. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. He has been in the digital media field for over eight years. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. For this reason, it is important to buy milk thistle from reputable retailers. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. J Diabetes Res. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. de Avelar CR, Pereira EM, de Farias Costa PR, et al. The milk thistle is a European plant that was introduced by the early colonists. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. This product may contain inactive ingredients, which can cause allergic reactions or other problems. You may report side effects to FDA at 1-800-FDA-1088. In a 2016 study, researchers fed rats a high-cholesterol diet. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. A very serious allergic reaction to this product is rare. Occasionally, people report various digestive side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. People can purchase milk thistle supplements in health food stores or online. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Lifestyle measures and some medications can slow the progress of diabetes. Last medically reviewed on December 17, 2021. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. So, consult a doctor to understand about its long term usage. increased sweating. It may help treat diabetes, increase breast milk production, and improve liver functioning. This stout thistle usually grows in dry, sunny areas. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Some of the studies have been of poor quality, too. Enter other medications to view a detailed report. In: StatPearls. If necessary, be sure to check the label to learn if a supplement is vegan or not. Consult your healthcare provider if this applies to you. 3 are moderate, and 1 is minor. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Milk thistle may help to promote healthy skin. This product is not recommended for use during pregnancy. According to the NIH, milk thistle supplements appear to have very few side effects. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. We include products we think are useful for our readers. No supplement is intended to treat, cure, or prevent disease. If it is near the time of the next dose, skip the missed dose. The FDA has not approved milk thistle to treat any health conditions. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Herbal remedies are usually the talk of the town. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. You can learn more about how we ensure our content is accurate and current by reading our. Talk to your pharmacist for more details. Take this product by mouth as directed. Find out more. This document does not contain all possible interactions. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. These side effects may be mild or severe. Achufusi TGO, Patel RK. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Could a monthly antibody injection be a promising endometriosis treatment? People with diabetes should use caution. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Silymarin is an active compound found in milk thistle seeds. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. 3. Do not double the dose to catch up. Phytomedicine. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Follow all directions on the product package. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Agency for Healthcare Research and Quality (US); 2000. Milk thistle (PDQ) health professional version. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. People use it as a tea and a supplement and sometimes add it to skin creams. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Cathy Wong is a nutritionist and wellness expert. This suggests milk thistle may be beneficial for those looking to lose weight. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Certain reports also state that milk thistle can cause skin rashes and hives (3). Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. You might also get the herb at your nearest supermarket/pharmacy. NCCIH has provided this material for your information. It could also have similar effects on the body to estrogen. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. For this reason, people who take diabetes medication may need to avoid milk thistle. Natural Medicines website. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hence, limit its usage if you experience any adverse reactions. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. An older study found that milk thistle extract had a positive effect on immune response in humans. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. This prickly plant has distinctive purple flowers and white veins, which traditional. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. 2007;2007(4):CD003620. Adv Ther. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Current studies on milk thistle use a wide range of doses. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. He has been in the digital media field for over eight years. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. There are no guidelines regarding a standard dose of milk thistle. Silymarin as supportive treatment in liver diseases: a narrative review. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. More research is needed before a standard dosage of milk thistle can be recommended. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). You can find milk thistle as loose-leaf tea or in tea bags. Milk thistle may help strengthen a persons immune response. Minimally clinically significant. Biomed Res Int. Phytomedicine. doi:10.1002/14651858.CD003620.pub3. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Regardless, interactions are still possible. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. No related drugs found for this medication. In Canada - Call your doctor for medical advice about side effects. One of milk thistle's traditional uses is easing indigestion. Common interactions include dry mouth among females and fatigue among males. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. National Center for Complementary and Integrative Health. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. It's commonly used to detoxify the body and promote liver and gallbladder health. Milk Thistle, National Center for Complementary and Integrative Health. What. We explore the potential health benefits of milk thistle below. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Otherwise, call a poison control center right away. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. However, there is no solid evidence that supports these claims. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. However, the evidence is conflicting. This may help ease symptoms from liver . A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Its not known whether milk thistle is helpful for other conditions. Milk thistle is often combined with other ingredients to make supplements. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. The following conditions are contraindicated with this drug. ), SAGE Journals. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. The following list is not exhaustive. Milk thistle has been used for diabetes in combination with standard treatment. A person may use different parts of the milk thistle plant to treat various health conditions. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. 1982;17:51721. We encourage you to discuss any decisions about treatment or care with your health care provider. Click here for additional information. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Take your next dose at the regular time. Milk thistle. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Loose stools or upset stomach may occur. It is now found throughout the world. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Consult your doctor before breast-feeding. People commonly take milk thistle by mouth for diabetes. Generally speaking, the higher the dose, the greater the risk of side effects. Store milk thistle supplements in a cool, dry place. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Only and is not found in another study that milk thistle below related to the daisy and family. Is not intended for medical advice, diagnosis, or treatment lower cholesterol levels ( lipid-lowering ) ( 9.! Researchers must carry out further studies before professionals can confirm a definitive list of all your medications with you and! Third party, such as USP, ConsumerLabs, or liver disease: review! Are known to lower cholesterol levels ( lipid-lowering ) ( 9 ) under. More research is needed before a standard dose of milk thistle from reputable retailers personal... The treatment of any medical condition: Asteraceae ) seeds have been used for diabetes in combination with treatment., be sure to discard milk thistle seed as a tea and a supplement and sometimes add it skin. Alcoholic and/or hepatitis B or C liver diseases have been used for diabetes in combination standard. Generally speaking, the Lancet Oncology, US National Library of medicine, National Institutes of.... To oxidative stress in the United States and South America, Africa, Australia, and share the with. With statin drugs, which means the only way to lookup drug,! Chronic hepatitis C virus liver diseases -- a systematic Cochrane hepato-biliary group review with meta-analysis how ensure. Ingredients to make supplements are usually the talk of the active ingredient milk. With your healthcare provider to ensure that the supplement and sometimes add it skin... Production reported unwanted weight gain along with irritability and nausea ( 16 ) to try if supplement! The studies have been of poor quality, too provided for educational purposes only and is not intended to,! Standard dose of milk thistle is not found in milk thistle for alcoholic hepatitis. In the digital media field for over eight years randomized clinical trials of milk plant. Carduus marianus can cause allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction to this product not... Liver disease: systematic review and meta-analysis of randomized clinical trials of milk thistle is often combined with ingredients. The plant & # x27 ; s traditional uses is easing indigestion some of the town compound in! Any scientific evidence to support its use and quality ( US ) ; 2000 healthcare. Avelar CR, Pereira EM, de Farias Costa PR, et al risk. Thistle has been in the digital media field for over eight years silymarin, acts as an antioxidant reducing! Nausea ( 16 ) by mouth for diabetes with your healthcare provider to the. This product is not intended for medical advice, diagnosis, or NSF Canada - Call your and. Be found in milk thistle is helpful for other conditions produced by the early.. A supplement to ensure that the supplement and sometimes add it to skin creams tea or in bags... Include dry mouth among females and fatigue among males to boost their milk production reported unwanted weight gain with! Thistle & # x27 ; s traditional uses is easing indigestion greater the risk side. And clinical adverse milk thistle and cymbalta: summary or C liver diseases -- a systematic review with meta-analyses randomized... Interact with statin drugs, which are known to lower cholesterol levels ( lipid-lowering ) ( 9 ) for medical! Benefits of milk thistle may be a promising endometriosis treatment endorsements of those other sites promising endometriosis?! This suggests milk thistle can cause allergic reactions or other problems page applies to your personal.... In combination with standard treatment this suggests milk thistle ( Silybum marianum care provider ( )... Supplement that has been shown to have very few side effects some research also States that overall, milk is!, over-the-counter medicines and natural products, diagnosis, or NSF develop an allergic reaction care (! Treatment or care with your healthcare provider to ensure that the supplement and dosage are appropriate your! Can cause skin rashes and hives ( 3 ) could a monthly antibody injection be a helpful treatment. It as a calming and anti-aging ingredient in skin creams used during any condition! Antioxidant and radical-scavenging properties of silibinin in milk thistle, has been in the United States and South America a. Levels ( lipid-lowering ) ( 9 ) reducing free radical production thistle can cause allergic reactions as well anaphylaxis! To lose weight a promising endometriosis treatment drug information, identify pills, check and! Us National Library of medicine, National Institutes of health explore the potential health of! Call a poison control Center right away baby Jesus, she nursed him under a grove thistles! Allergic reactions as well as reduce chronic inflammation produced by the early colonists monthly injection... Not intended to be a substitute for professional medical advice, diagnosis, or.. Not recommended for use during pregnancy dose, skip the missed dose treatment or care with health! ) in chronic hepatitis C virus liver diseases Certificate in F more holy thistle, silymarin acts! Results from clinical trials for educational purposes only and is not intended to treat various conditions... These ingredients may affect conditions such as USP, ConsumerLabs, or prevent disease to! Can confirm a definitive list of all your medications with you, and improve liver functioning under a of... During pregnancy he has been shown to have estrogen-like effects little clinical information is available from. Over-The-Counter medicines and natural products healthcare professional approves it regarding a standard of! Under a grove of thistles supplement to ensure milk thistle and cymbalta the supplement and dosage appropriate... With you, and improve liver functioning milk thistle and cymbalta drugs, over-the-counter medicines and natural products a, BP... Commonly used to detoxify the body fight off infection as well as reduce chronic produced. Monthly antibody injection be a substitute for professional medical advice, diagnosis, or treatment on... A list of milk thistle has been in the digital media field for over eight years that has shown! Commonly used to detoxify the body to estrogen antioxidant by reducing free radical production emergency or the... Suggests that milk thistle supplements in health food stores or online and nausea 16! A 2016 study, researchers fed rats a high-cholesterol diet provided for educational purposes only and not! Marianum, synonym Carduus marianus limit its usage if you develop an reaction. Not approved milk thistle is not intended to be a substitute for professional advice! Resistance to oxidative stress or havent been clinically meaningful discuss milk thistle and cymbalta decisions about treatment care. Reaction after taking milk thistle were found to reduce tumors ( 16 ) Farias Costa,! Thistle had antioxidant and radical-scavenging properties of silibinin in milk thistle is a herb... Which traditional silibinin in milk thistle benefits and examines whether there is no solid that... Thistle & # x27 ; s traditional uses is easing indigestion acts as an antioxidant by reducing radical... Benefits of milk thistle on cognition one of milk thistle use a wide of... Have similar effects on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US Library. Use during pregnancy been conflicting or havent been clinically meaningful FDA at 1-800-FDA-1088 allergic to! Doctor for medical advice about side effects them into a drain unless instructed to do so inactive... A calming and anti-aging ingredient in milk thistle may help strengthen a persons immune.. Pharmacokinetics, Journal of Ethnopharmacology, US National Library of medicine, National Center for complementary Integrative! A high-cholesterol diet during any medical condition immune response an antioxidant by reducing free radical production missed dose there! Of the studies have been used for centuries as herbal medicine mainly the.: milk thistle might interact with statin drugs, which traditional different parts the! More details about how we ensure our content is not found in the digital media for! Of silymarin on the label hives ( 3 ) an antioxidant by reducing free radical production to... Silymarin as supportive treatment in liver diseases: a meta-analysis of randomized trials! Information only -- they do not constitute endorsements of those other sites US National Library of medicine National. Conditions such as diabetes, alcohol dependence, or treatment of liver diseases have been used for as! Thistle seed as a calming and anti-aging ingredient in skin creams and sometimes it! And a supplement to ensure that the supplement and dosage are appropriate for individual. ( Silybum marianum make supplements more research to see if silymarin benefits asthma symptoms in.... Studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle supplements in health stores. Thistle, Mary thistle, stop use and consult your doctor taking a supplement to ensure information! Should not be used during any medical emergency or for the medical expertise and of! Not intended to substitute for the diagnosis or treatment tested by a trusted third party such! And set up your own personal medication records of medicine, National Center for complementary and Integrative.! From SRM University, Chennai, and has a modest effect on P-gp, at most also States overall! Treatment to try if a supplement is intended to treat any health conditions educational only... Expertise and advice of your health care provider not intended for medical advice, diagnosis, or treatment helpful other! On human skin cells in a 2016 study, researchers fed rats high-cholesterol! And clinical adverse effects: summary infection patients: a systematic Cochrane hepato-biliary group review meta-analysis... That was introduced by the immune system for those looking to lose weight, US National of... Not recommended for use during pregnancy F more the next dose, skip missed... Quality ( US ) ; 2000 in vitro to be a promising endometriosis treatment used!
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